taurodeoxycholic acid tdca  (steraloids inc)

Journal: Frontiers in Physiology

Article Title: Profiling bile acid composition in bile from mice of different ages and sexes

doi: 10.3389/fphys.2025.1626215

Figure Lengend Snippet: MRM chromatograms of all quantitative BAs. 1. TωMCA, 2. TαMCA, 3. TβMCA, 4. THCA, 5. TUDCA, 6. THDCA, 7. TCA, 8. ωMCA, 9. αMCA, 10. GCA, 11. βMCA, 12. TCDCA, 13. TDCA, 14. CA, 15. UDCA, 16. HDCA, 17. GCDCA, and 18. CDCA.

Article Snippet: BA standards, including cholic acid (CA) (Cat. No. C1900-015), glycocholic acid (GCA) (Cat. No. C1925-000), taurocholic acid (TCA) (Cat. No. C1965-000), CDCA (Cat. No. C0940-000), glycochenodeoxycholic acid (GCDCA) (Cat. No. C0962-000), taurochenodeoxycholic acid (TCDCA) (Cat. No. C0990-000), α-muricholic acid (αMCA) (Cat. No. C1890-000), β-muricholic acid (βMCA) (Cat. No. C1895-000), tauro α-muricholic acid (TαMCA) (Cat. No. C1893-000), tauro β-muricholic acid (TβMCA) (Cat. No. C1899-000), ursodeoxycholic acid (UDCA) (Cat. No. C1020-000), TUDCA (Cat. No. C1052-000), taurodeoxycholic acid (TDCA) (Cat. No. C1162-000), taurohyocholic acid (THCA) (Cat. No. C1887-000), HDCA (Cat. No. C0860-000), taurohyodeoxycholic acid (THDCA) (Cat. No. C0892-000), ω-muricholic acid (ωMCA) (Cat. No. C1888-000), and tauro ω-muricholic acid (TωMCA) (Cat. No. C1889-000) were purchased from Steraloids Inc. (Newport, RI, United States).

Techniques:

Journal: Frontiers in Physiology

Article Title: Profiling bile acid composition in bile from mice of different ages and sexes

doi: 10.3389/fphys.2025.1626215

Figure Lengend Snippet: Comparison of TBA levels and BA composition in 8-week-old and 60-week-old mice. (A) TBA levels at the two ages. (B) PCBA, PUBA, SCBA, and SUBA levels at the two ages. (C) BA percentage compositions at the two ages. (D) Individual BA levels at the two ages. TBAs, total BAs, the sum of all individual BAs detected; 8W, 8-week; 60W, 60-week; PCBAs: TCA, GCA, TCDCA, GCDCA, TαMCA, TβMCA, and TUDCA; PUBAs: CA, CDCA, αMCA, βMCA, and UDCA; SCBAs: TωMCA, TDCA, THCA, and THDCA; SUBAs: ωMCA and HDCA; *p < 0.05 and **p < 0.01; sample size: n = 24 for 8W and n = 28 for 60W.

Article Snippet: BA standards, including cholic acid (CA) (Cat. No. C1900-015), glycocholic acid (GCA) (Cat. No. C1925-000), taurocholic acid (TCA) (Cat. No. C1965-000), CDCA (Cat. No. C0940-000), glycochenodeoxycholic acid (GCDCA) (Cat. No. C0962-000), taurochenodeoxycholic acid (TCDCA) (Cat. No. C0990-000), α-muricholic acid (αMCA) (Cat. No. C1890-000), β-muricholic acid (βMCA) (Cat. No. C1895-000), tauro α-muricholic acid (TαMCA) (Cat. No. C1893-000), tauro β-muricholic acid (TβMCA) (Cat. No. C1899-000), ursodeoxycholic acid (UDCA) (Cat. No. C1020-000), TUDCA (Cat. No. C1052-000), taurodeoxycholic acid (TDCA) (Cat. No. C1162-000), taurohyocholic acid (THCA) (Cat. No. C1887-000), HDCA (Cat. No. C0860-000), taurohyodeoxycholic acid (THDCA) (Cat. No. C0892-000), ω-muricholic acid (ωMCA) (Cat. No. C1888-000), and tauro ω-muricholic acid (TωMCA) (Cat. No. C1889-000) were purchased from Steraloids Inc. (Newport, RI, United States).

Techniques: Comparison

Journal: International Journal of Molecular Sciences

Article Title: Evidence for the Worldwide Distribution of a Bile Salt Hydrolase Gene in Enterococcus faecium Through Horizontal Gene Transfer

doi: 10.3390/ijms26020612

Figure Lengend Snippet: Enzymatic characterization of EfpBSH. ( A ) BSH activity and substrate specificity of EfpBSH. The tested substrates were glycocholic acid (GCA), glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), taurocholic acid (TCA), taurochenodeoxycholic acid (TCDCA), and taurodeoxycholic acid (TDCA). Each bile salt solution was mixed with buffer instead of EfpBSH (white bars) for specific negative controls. Values are indicated as means of five technical replicates ( n = 5). Error bars represent standard deviation (SD). Identification of the effects of temperature ( B ) and pH ( C ) on BSH activity. The tested temperature and pH ranges were 20–80 °C and pH 3.0–10.0, respectively. Each value is expressed as the mean of three technical replicates ( n = 3). Maximum activity was taken as 100%. Error bars indicate SD. For all analyses, a p -value less than 0.05 (* p < 0.05) was defined as statistically significant.

Article Snippet: The tested substrates were glycocholic acid (GCA, Cayman Chemical, Ann Arbor, MI, USA), glycochenodeoxycholic acid (GCDCA; Sigma-Aldrich, St. Louis, MO, USA), glycodeoxycholic acid (GDCA; Sigma-Aldrich), taurocholic acid (TCA; Nacalai Tesque), taurochenodeoxycholic acid (TCDCA; Sigma-Aldrich), and taurodeoxycholic acid (TDCA, Nacalai Tesque).

Techniques: Activity Assay, Standard Deviation

Journal: Biomedicines

Article Title: Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis

doi: 10.3390/biomedicines13010078

Figure Lengend Snippet: Plasma bile acid comparisons between the hepatitis and control groups.

Article Snippet: LCA, CA, DCA, CDCA, tauroursodeoxycholic acid (TUDCA), glycochenodeoxycholic acid (GCDCA), taurodeoxycholic acid (TDCA), glycocholic acid (GCA), and taurocholic acid (TCA) were from Nacalai Tesque (Cat No: 09174-54, 08843-14, 10711-64, 07938-01, 32731-24, 17132-44, 32740-91, 17123-51 and 32729-61, respectively; Kyoto, Japan).

Techniques: Clinical Proteomics, Control

Journal: Biomedicines

Article Title: Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis

doi: 10.3390/biomedicines13010078

Figure Lengend Snippet: Specific bile acids show strong positive correlations with liver damage markers in the hepatitis and control groups. Pearson’s correlation coefficients of the 19 blood samples are visualized as heat maps, highlighting significant differences between the hepatitis and control groups. The correlation strength is classified as follows: 0.7 < |r| < 1.0 indicates a strong correlation. Total bilirubin (TBIL), direct bilirubin (DBIL), and aspartate transaminase (AST) were strongly and positively correlated with tauroursodeoxycholic acid (TUDCA) and glycochenodeoxycholic acid (GCDCA).

Article Snippet: LCA, CA, DCA, CDCA, tauroursodeoxycholic acid (TUDCA), glycochenodeoxycholic acid (GCDCA), taurodeoxycholic acid (TDCA), glycocholic acid (GCA), and taurocholic acid (TCA) were from Nacalai Tesque (Cat No: 09174-54, 08843-14, 10711-64, 07938-01, 32731-24, 17132-44, 32740-91, 17123-51 and 32729-61, respectively; Kyoto, Japan).

Techniques: Control

Journal: Biomedicines

Article Title: Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis

doi: 10.3390/biomedicines13010078

Figure Lengend Snippet: Bile acids show strong positive correlations with liver damage indicators in the hepatitis and control groups. Pearson’s correlation coefficients of the 19 blood samples are visualized as heat maps, illustrating significant relationships between bile acids, liver reserve, and liver fibrosis. The correlation strength is classified as follows: 0.7 < |r| < 1.0 indicates a strong correlation. Child–Pugh (CP), fibrosis-4 (FIB-4), and non-alcoholic fatty liver disease (NAFLD, also known as MASLD) fibrosis score (NFS) showed strong positive correlations with glycocholic acid (GCA). Similarly, the aspartate aminotransferase-to-platelet ratio index (APRI) was strongly correlated with taurocholic acid (TCA), taurochenodeoxycholic acid (TCDCA), and GCA. The model for end-stage liver disease (MELD) showed a strong positive correlation with glycochenodeoxycholic acid (GCDCA).

Article Snippet: LCA, CA, DCA, CDCA, tauroursodeoxycholic acid (TUDCA), glycochenodeoxycholic acid (GCDCA), taurodeoxycholic acid (TDCA), glycocholic acid (GCA), and taurocholic acid (TCA) were from Nacalai Tesque (Cat No: 09174-54, 08843-14, 10711-64, 07938-01, 32731-24, 17132-44, 32740-91, 17123-51 and 32729-61, respectively; Kyoto, Japan).

Techniques: Control

Journal: Biomedicines

Article Title: Targeted Plasma Bile Acid Metabolomic Analysis in Metabolic Dysfunction-Associated Steatohepatitis and Alcoholic Hepatitis

doi: 10.3390/biomedicines13010078

Figure Lengend Snippet: A total of 8 bile acids with under the curve (AUC) value >0.700 are shown. The AUC values for ursodeoxycholic acid (UDCA), chenodeoxycholic acid (CDCA), taurocholic acid (TCA), tauroursodeoxycholic acid (TUDCA), taurochenodeoxycholic acid (TCDCA), glycoursodeoxycholic acid (GUDCA), glycochenodeoxycholic acid (GCDCA), and glycocholic acid (GCA) were 0.900, 0.811, 0,922, 0.950, 0.906, 0.928, 0.889 and 0.944, respectively. The cutoff values were as follows: UDCA was 21.02 pmol/mL, CDCA was 56.77 pmol/mL, TCA was 187.49 pmol/mL, TUDCA was 22.64 pmol/mL, TCDCA was 643.25 pmol/mL, GUDCA was 72.71 pmol/mL, GCDCA was 1647.77 pmol/mL, and GCA was 619.79 pmol/mL.

Article Snippet: LCA, CA, DCA, CDCA, tauroursodeoxycholic acid (TUDCA), glycochenodeoxycholic acid (GCDCA), taurodeoxycholic acid (TDCA), glycocholic acid (GCA), and taurocholic acid (TCA) were from Nacalai Tesque (Cat No: 09174-54, 08843-14, 10711-64, 07938-01, 32731-24, 17132-44, 32740-91, 17123-51 and 32729-61, respectively; Kyoto, Japan).

Techniques: